mntA [2017-8-11 16:0:3]

manganese ABC transporter (binding protein, lipoprotein)

locus: BSU30770

pI: 6.16

mw: 33.26 kDa

protein length: 306 aa

gene length: 918 bp

function: manganese uptake

product: manganese ABC transporter (binding protein)

essential: no

synonyms: ytgA

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.6|Uptake of ions]
• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.2|Manganese]
• [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]

Gene

Coordinates: 3,145,038 → 3,145,958

Phenotypes of a mutant

• essential according to [http://www.ncbi.nlm.nih.gov/pubmed/17114254 Kobayashi et al.], but a mutant has been constructed and studied by [http://www.ncbi.nlm.nih.gov/pubmed/10760146 Que and Helmann, 2000]

The protein

Protein family

• bacterial solute-binding protein 9 family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|D33A144568CAF32FFE4A2A46BE67573DB66FC1A1|ZnuA]

[SW|Localization]

• cell membrane (according to Swiss-Prot), extracellular lipoprotein (signal peptide) [Pubmed|18957862]

Expression and Regulation

Operons

• genes: [gene|3C40A6E42A669E77ADBF5FFF334061C51F76A4F9|mntA]-[gene|7821C82C6C30079F713B84F1E4D654E07CE5072E|mntB]-[gene|1B7C4AD6CD0632051A0E8CA57034872D13FF67F9|mntC]-[gene|F7DA077FE47DBB409BE2B1D9F12A9D719C246166|mntD]
  description: [Pubmed|10760146]

  regulatory mechanism

  • [protein|FF34DC303E8A7C9FAA205A6C2924961963B14EB1|MntR]: repression, [Pubmed|12950915], in [regulon|FF34DC303E8A7C9FAA205A6C2924961963B14EB1|MntR regulon]

  regulation

  • repressed at high Mn(II) concentrations ([protein|search|MntR]) [Pubmed|12950915]

  additional information

  • A [protein|search|ncRNA] is predicted between '[protein|search|mntA]' and '[protein|search|menC]' [PubMed|20525796]

Biological materials

Mutant

• MGNA-A285 (ytgA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/285 NBRP B. subtilis, Japan]

Labs working on this gene/protein

• [SW|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]

References

• 10760146,10092453,12950915,10760146,18957862,10760146,17114254,20525796